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Artificial pancreas tested in humans

Dave Sherohman's picture

Results are in on initial one-day overnight trials of an artificial pancreas and they sound promising:

Quote:

researchers found that nearly 100 percent of all overnight data from the closed-loop sessions were within the target range of 70 to 180 mg/dl, and the time patients spent with blood glucose levels falling within the narrower 70 to 140 mg/dl range increased from 65 percent to 78 percent from open-loop to closed-loop control.

LSF and INGAP for type 1 diabetes

Dave Sherohman's picture

Yet another group of mice have been cured of type 1 diabetes, this time using a combination of the drugs LSF (Lisofylline), a targeted immunosuppressant, and INGAP (Islet Neogenesis Associated Protein peptide), which promotes regrowth of pancreatic islet cells. I had heard rumors that research was being done with this kind of drug combination, but this is the first time I've found details on such a study.

In this trial, 70% of mice were shown to be cured of type 1 diabetes by this combination of drugs. By "cured", I mean that blood sugar levels remained normal even after all diabetes treatment was stopped, although I'm sure that, if this works in humans, our longer lifespan would leave us susceptible to re-onset of diabetes if we were to encounter another environmental trigger which restarted the anti-beta-cell autoimmune response.